Not really. There will be more data and connections to analyse during the final part of the game, but the early stages should be quite similar. The main difficulty for towns in large games is that people will often have very different posting rates. Towns should as much as possible try to have similar posting rates (this include not lurking, but also not drowning the thread with quote wars)
You can also assume more easily the presence of some roles when planning night actions. The odds of a town protective role and a mafia roleblocking role are extremely high in the usual large games.
Commonly Asked Questions on Mafia Theory
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