Goats is one of the oldest webcomics, at over 9 years old. Goats started out as a pseudo-autobiographical strip and mutated into a sci-fi monstrosity. There's no good way to summarize it but basically it centers around the adventures of two bar patrons, their pets and the increasingly strange people that they meet.
Knowledge of the theme is not required. I will answer any theme-related questions you may have and the website has many helpful features, such as a short summary of the story so far, short bios of the important characters and a fully integrated search function. Basically, your enjoyment of this game does not in any way rely on you knowing anything about the theme.
Alive(6):
8. Ibaesha
9. Coron
10. The Goat
15. Sarcastro
19. twito
22. mikeburnfire
Dead(16):
5. BrianMcQueso, Space Hitler, Delayed SK, beaten up Night 1.
18. Yosarian2, Tommy, townie, strangled Night 1.
20. BabyJesus, Mutant Pea Plant, Scientist Henchman, head blown off Night 1.
14. three word name, Over-clocked Lemon, Decultifier, head blown off Night 2.
16. Glork, Carl, Biker Goon, strangled Night 2.
17. bluesoul, Steve, Role Name Investigator, beaten up Night 2.
3. Nemesis, Toothgnip, Role Gender Investigator, lynched day 2.
11. the silent speaker, Fish/Fineas, Townie/Overeager Vigilante, strangled Night 3.
12. Rosso Carne, Lori, Townie, burned to a crisp Night 3.
21. chamber, Mutant Pea Plant, Scientist Henchman, shot Night 3.
13. PookyTheMagicalBear, Roger, Biker Goon, KOed Night 4.
6. Mariyta
1. Romanus
2. Fritzler, Gus, Role Name Investigator, head blown off Night 5.
7. Machiavellian-Mafia, Diablo, Unshazammable Townie, KOed Night 5.
4. Mastermind of Sin, Gregor Mendel, Mad Scientist, lynched Day 5.